Excellent discussion, everyone!
I am still in the unit pump/injector wannabe group and have at least a half dozen versions of the "so close you can taste it," category in the boxes of failures. Designing to a minimal number of critical sealing surfaces seems to be the most workable goal for the home shop, but I have take apart a yanmar pump-line-injector setup, and a detroit diesel unit injector, both of which use the lapped plunger with rotating helix spill design for volume control. Both of these in stock form produce a perfect cloud of vapor-fine mist when operated. The fit of the plunger into the pump body is an order of magnitude better than anything that I can produce. The fit is almost magically good, LOL. But they are made to work for 1,000's of hours. I would be happy with minutes.
Our nemesis of scaling factor is one problem. If you try to make a pump of 1/3 scale, the pump volume will be 1/27 BUT, the area of the sealing surfaces will be 1/9. So you essentially have 3 times as much leak potential as a full sized unit. I was told by a retired diesel expert, that any type of elastomeric material in the high pressure side will lead to inaccuracies in fuel delivery. I am still holding hope that a good governor will be able to overcome some of that issue. But the real injectors all seem to have an abundance of both flat and cylindrical lapped surface, all of which are critical.
Seal material choice is critical. Look up compatibility info with diesel fuel and as already noted, Viton and teflon might be the best possibilities, except for a few very expensive specialty compounds. Some material might work perfectly today, but after sitting for 2 days have swelled and locked up.
I am at the point that most of my failures have actually somewhat worked, but none have worked "well", at least for any length of time. Attention to detail, tenacity, project burn-out, are all critical factors. I am again, at the almost-there on another variation and I remain optimistic. Others have succeeded, so there is probably no reason that any of us should not be successful, too.
Lloyd