I used to run YS 4-strokes when I flew RC pattern, then got into pylon (2-stroke HP engines). So I have a bit of hands on experience. Since the 140 4S generation, they have increased in complexity & power. Now direct injection (vs pseudo induction boost) & electronic ignition (vs glow). I would google & study engines like these for sizing & materials etc, because if anything they are probably conservative to what you are embarking on.
http://www.ysengines.net/dz170-cdi/
http://www.gbrcaa.org/smf/index.php?topic=1440.0
On one hand, ignition system is more sophisticated vs glow, but I think net better decision. Varying nitro content in methanol inherantly affects glow plug ignition timing, and sometimes in a not-good way. We typically play with plug selection (varying heat settings) & alter head shims (compression alteration) not just for power, but prevent destructive detonation. And these tweaks are required when the fuel (%nitro) is fully known beforehand. I can tell you that a setup suitable for stock 15% nitro is completely different than 45%, probably the max I ever ran. But at these compression levels, a couple thou thickness in shims is actually pretty noticeable. Some of the HP boaters would run higher nitro, but they had water cooling & even then melted a few along the way. Altering nitro on the fly introduces more variables, least of which will be ignition timing. So I suspect you will likely require a way advance/****** that on the fly as well?
Heat starts to become a lot more problematic at these levels, so that will tax the lube system. The alloys used in pistons, heads, chromed liners etc is pretty sophisticated stuff. Not taking anything away from your exciting project, but I would try & sponge as much information from existing engines as you can.