Hi Andrew, On setting the eccentric for a steam engine, you should not go far wrong when set 15 degrees ahead of BDC for exhaust valves just opening... or inlet just opening at TDC? - I have used both as a starting point then tweaked to optimise depending on use of the engine.
Of course, a lot depends upon the geometry of inlet and exhaust opening and closing times, arrangement of eccentric linkage, etc. - Which is why there are so many different geometries of valve gear, Joy, Stephensons, Walschearts, etc...
The Steam equivalent of the piston ported "valve-less" 2-stroke IC engine would always be the Oscillating engine, - which can be made without worrying about valve timings. Just drill ports accurately according to "the book".
N.B. Joining engines in series, as suggested by our old friend Bentwings, can cause some strange effects in flexible couplings by different cylinders getting a bit ahead or behind others, and setting-up some terrible (destructive?) torsional vibrations.... When a resonance occurs they fight each other until the coupling is over-stressed and fails. Far better to have torsionally rigid couplings with "perfect" alignment.
I suggest you do as "a majority" of modellers have done.... Make a small steam engine - and make it run and power something. This will prove your skills at making things like pistons and bores that fit properly, crank-shafts that are not misaligned, valves that seal, bearings that do not rattle or seize, etc.
Then you can use the proven skills to make small IC engines. Start with a piston ported 2 stroke to prove you can make a runner with good compression.
A half-inch to 1 inch bore and stroke is a reasonable starter model - steam or 2-stroke IC - before you get too ambitious and go smaller or bigger! (I started with a 1/2" bore and 3/4" stroke V-twin steam oscillator - because the kit was cheap. Learned a lot!).
Then think about 4-stroke IC valves and valve gears! Modelling is an education in precision manufacture, so always use the best tools and materials you have or can afford.
And always ENJOY the hobby. We all make mistakes - then discuss solutions or lessons learned on this website. A good way to learn is from mistakes - hopefully others' mistakes, not your own.
K2